Selected Publications

For a full list of publications, see Scholar

Opinion Article: Fly immunity comes of age: The utility of Drosophila as a model for studying variation in immunosenescence
Corbally, M. K., & Regan, J. C. (2022) In: Frontiers in Aging, 108.                                                                                                                                          DOI:https://doi.org/10.3389/fragi.2022.1016962

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
Juricic, P., et al. (2022) In: Nature Aging 2(9), 824-836.                                                                                                                                      DOI:https://doi.org/10.1038/s43587-022-00278-w

Sexual identity of enterocytes regulates rapamycin-mediated intestinal homeostasis and lifespan extension
Regan, J. C. & Lu, Y. X., et al. (2021) In: bioRvix                                                                                                                                                                DOI:https://doi.org/10.1101/2021.10.22.465415

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
Lu, Y. X., Regan, J. C., Eßer, J., et al. (2021) In: eLIFE 2021 May 14;10:e62233.                                                                                                              DOI:https://doi.org/10.1371/journal.pgen.1009083

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila
Bjedov I, Cochemé HM, Foley A, et al. (2020) In: PLOS Genetics                                                                                                                                    
DOI: https://doi.org/10.1371/journal.pgen.1009083

Lifespan Extension Via Dietary Restriction: Time to Reconsider the Evolutionary Mechanisms?
Moatt, J.P., Savola, E., Regan, J.C. Nussey, D.H. and Walling, C.A. (2020) In: BioEssays
DOI: https://doi.org/10.1002/bies.201900241 

Sexual Dimorphism in Innate Immunity and Responses to Infection in Drosophila melanogaster
Belmonte, R.L., Corbally, M., Duneau, D.F. and Regan, J.C. (2020) In: Frontiers in Immunology
DOI: https://doi.org/10.3389/fimmu.2019.03075

Dietary restriction and insulin‐like signalling pathways as adaptive plasticity: A synthesis and re‐evaluation
Regan, J.C., Froy, H., Walling, C.A., Moatt, J.P.,& Nussey, D.H. (2020) In: Functional Ecology
DOI:
https://doi.org/10.1111/1365-2435.13418

Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes
Regan, J.C., Lu, Y., Bolukbasi, E., Khericha, M., and Partridge, L. (2018) In: bioRxiv
DOI:
https://doi.org/10.1101/356295

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
Bolukbasi, E., Khericha, M., Regan, J.C. et al. (2017) In: Cell Reports, vol. 21, no. 3, pp. 641-653 
DOI:
https://doi.org/10.1016/j.celrep.2017.09.042

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
Regan, J.C., Khericha, M., Dobson, A.J., Bolukbasi, E., Rattanavirotkul, N. and Partrigde, L. (2016) In: eLIFE, vol. 5 
DOI:
https://doi.org/10.7554/eLife.10956

Steroid hormone signaling is essential to regulate innate immune cells and fight bacterial infection in Drosophila
Regan, J.C., Brandao, A.S., Leitao, A.B., Mantas Dias, A.R., Sucena, E. and Jacinto, A. (2013) In: PLOS Pathogens, vol. 9, no. 10
DOI: https://doi.org/10.1371/journal.ppat.1003720

Gender and longevity: why men die earlier than women - biological and experimental evidence
Regan,J.C. and Partridge, L. (2013)  In: Best practice & research. Clinical endocrinology & metabolism, vol. 27, no. 4, pp. 467-479
DOI:
https://doi.org/10.1016/j.beem.2013.05.016

Drosophila Hemocyte Migration - in vivo Assay for Directional Cell Migration
Moreira, C., Regan, J.C., Zaidman-Remy, A.,Jacinto, A. and Prag, S. (2011) In: Cell Migration, vol769, pp249-260
DOI:
https://doi.org/10.1007/978-1-61779-207-6_17

The Drosophila larva as a tool to study gut associated macrophages: PI3K regulates a discrete population of hemocytes at the proventriculus
Zaidman-Remy, A., Regan, J.C., Brandao, A.S. and Jacinto, A. (2011) In: Developmental and Comparative Immunology, vol. 36, no. 4
DOI:
https://doi.org/10.1016/j.dci.2011.10.013

An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry
Regan, J.C., Concha, M.L., Raussigne, M.,Russel, C. and Wilson S.W. (2009) In: Neuron, vol. 61, no. 1, pp. 27-34
DOI:
https://doi.org/10.1016/j.neuron.2008.11.030